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Her recent work uncovered a critical epigenetic mechanism driving brain metastasis in triple-negative breast cancer, identifying KDM6A as a key mediator and potential therapeutic target šŸ“„ www.nature.com/articles/s41...
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Seehawer et al. show that deletion of Kmt2c or Kmt2d promotes brain metastasis in mouse models of triple-negative breast cancer due to altered KDM6A activity and upregulated MMP3 expression, which may...
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Loss of Kmt2c or Kmt2d drives brain metastasis via KDM6A-dependent upregulation of MMP3 - Nature Cell Biology
Metastasis Research Society