Head of the Genome Integrity Unit, Children's Medical Research Institute. Professor, University of Sydney.
Tony Cesare
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A brilliant editorial by @mafdawson.bsky.social and @hilliardlab.bsky.social highlighting frustrations many Australian scientists feel about the decline of peer review standards for NHMRC funding.
I wholeheartedly agree.
www.science.org/doi/10.1126/...
@zeiss-microscopy.bsky.social Cell Discoverer 7 now up and running @cmri.bsky.social.
Tony Cesare
Tony Cesare
A key concept is that telomere “deprotection” is a regulated process that enables loss of t-loops to signal growth arrest or cell death without compromising genome integrity.
We also discuss how telomere shortening during ageing may drive t-loop destabilisation and cellular senescence.
Applause to Mark and Massimo for having the courage to put their names to this. Well done.
@lisannes.bsky.social gave an outstanding seminar at @cmri.bsky.social yesterday.
Full room, exciting data, and a 15-minute Q&A -- a fantastic discussion.
Amazing work, Lisanne. Thank you for visiting and sharing it with the institute.
Registration open for the @garvaninstitute.bsky.social Signalling Symposium.
linktr.ee/garvansignal...
An important seasonal installation in the Cesare lab. March Madness bracket is up.
Go Tar Heels! 🏀
This piece explores how telomeres are not static chromosome-end caps, but dynamic DNA structures that actively regulate genome surveillance and cell fate.
We focus on telomere loops (t-loops) and their role in regulating DNA damage response activation at natural chromosome termini.
“T-loop Dynamics: Telomere Structure Shapes Cell Fate Decisions” is out now in @cp-trendscellbio.bsky.social .
www.cell.com/trends/cell-...
It was a pleasure to work on this with collaborator and friend @makotothayashi.bsky.social, whose insight was central to shaping the ideas in this review.
We also discuss how deprotected telomeres can persist across cell cycles, and how normally protective telomere-binding proteins can actively promote deprotection to signal mitotic stress.
Grateful to the many colleagues whose work and ideas have contributed to these concepts over the years.
Tony Cesare
Tony Cesare
Tony Cesare
Tony Cesare
Tony Cesare
Tony Cesare
Tony Cesare
Tony Cesare
Throughout the world, peer review serves as the cornerstone of the scientific enterprise, providing rigorous quality control and building the confidence that underpins progress for both science and so...
